Allodynia, rigidity and gait disturbance

CLINICAL CASE

A 57-year-old woman presented with gait disturbance and falls. Two months before, she had first developed stiffness and painful spasms in her lower back and thighs. These sy7mptoms had worsened on trying to stand or walk, persisted while sleeping and progressed. She had no weakness, sensory loss or sphincter disturbance. There was no apparent infective trigger, no fever, weight loss, or other systemic symptoms. Over the previous year, she had been assessed for fatigue, dyspareunia, anxiety and insomnia. She smoked 10 cigarettes a day.

On examination, her mental status and cranial nerves were normal. She had normal muscle strength in all groups but there was axial and proximal stiffness in lower limbs, with spasms and delayed muscle relaxation after voluntary activation; the right leg was more affected than the left. Reflexes were globally exaggerated with both plantar responses flexor. There was no myotonia, fasciculation or other signs of spontaneous…

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