Distinctive lesions of brain MRI between MOG-antibody-associated and AQP4-antibody-associated diseases

Introduction

The autoantibody against myelin oligodendrocyte glycoprotein (MOG) is present in patients with several inflammatory diseases such as neuromyelitis optica spectrum disorder (NMOSD), acute disseminated encephalomyelitis (ADEM), optic neuritis and transverse myelitis. Differential diagnosis is difficult because of overlapping clinical and radiological features.1

In adult patients with MOG-Ab-associated disease (MOGAD), the highest occurrence of lesions was in the thalamus and pons in MOGADOR study,1 but the other study showed that MOGAD lesion was more often found in subcortical white matter and the internal capsule, but the pontine lesion was not revealed as distinct.2 In paediatric patients, the cerebellar peduncle was dominant in MOGAD, but there were no statistically significant differences in the pons, thalamus and cortical lesions.3 Such discrepancies might suggest a wide diversity in lesion configuration and extraction, range of diseases and various age of disease onsets.

In our large-scale study, we divided…

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