Long-term risk of chronic epilepsy in adults after post-anoxic coma and refractory status epilepticus: a retrospective cohort study

Introduction

Refractory status epilepticus (RSE) has been reported in 20%–30% of patients in coma after cardiac arrest,1 but aggressive and prolonged treatment of RSE in patients with favourable multimodal prognostic indicators might lead to 40%–50% survival and good neurological outcome.2 However, scarce data are available on chronic epilepsy after cardiac arrest, which may severely impair the quality of life in survivors. It is unclear whether these patients are at risk of epilepsy, and whether the occurrence of RSE in the acute phase increases such risk. We investigated the risk of epilepsy in a cohort of cardiac arrest survivors.

MethodsStudy design

This is a retrospective cohort study approved by the Ethics Committee of San Gerardo Hospital, Monza, Italy, based on a previous prospective study.2 Between January 2011 and May 2016, consecutive adult patients with cardiac arrest treated with hypothermia (34°C), in coma for >24 hours, underwent simplified 4-channel…

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