Plasma glial fibrillary acidic protein and neurofilament light chain are measures of disease severity in semantic variant primary progressive aphasia


Semantic variant primary progressive aphasia (svPPA) is a neurodegenerative disorder characterised by loss of conceptual knowledge, commonly presenting with word-finding difficulties, impaired single word comprehension and focal atrophy of the temporal lobe.1 It is a subtype of frontotemporal dementia (FTD) and usually associated with TDP-43 type C pathology. While much progress has been made in the last 20 years in understanding the cognitive and biological nature of svPPA, there have been limited studies of fluid biomarkers.2 In this study, we investigated the role of plasma glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) as biomarkers for astroglial activation and neurodegeneration in svPPA, as well as their association with disease severity in svPPA.


Plasma samples were collected from 64 consecutively recruited participants from the University College London FTD cohort studies: 28 participants meeting diagnostic criteria for svPPA1 and 36 healthy controls….

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