Randomised controlled trial of naming outcomes in anterior temporal lobectomy versus selective amygdalohippocampectomy


Surgery for medically refractory temporal lobe epilepsy (TLE) is well established, with favourable outcomes in seizure control, patient quality of life (QOL) and treatment costs.1 2 However, postoperative cognitive decline is a concern. Dysnomia is reported in 25%–60% of patients following anterior temporal lobectomy (ATL) in the dominant hemisphere.3 Selective amygdalohippocampectomy (SAH) is an alternative procedure in which temporal neocortex is spared to reduce functional impairment. No controlled studies have been conducted to demonstrate superior outcomes of either procedure. There is an imperative to establish whether SAH better preserves neuropsychological functioning without foregoing the seizure benefits of a more extensive resection. This study aimed to identify differential naming outcomes of SAH and ATL using a randomised controlled trial (RCT) design.


A parallel-group, single-centre RCT was conducted at a tertiary healthcare facility between 2012 and 2018. The trial was discontinued due to a diminishing…

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