A case of CIDP concurrent with MGUS IgG kappa responsive to autologous stem cell transplantation

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an acquired immune-mediated disease of the peripheral nervous system, either being isolated or associated with other systemic diseases, most frequently with lymphoproliferative subtypes.1 CIDP concurrent with monoclonal gammopathy of undetermined significance (MGUS) accounts for up to 20%–30% of all cases,2 is often considered clinically indistinguishable from typical CIDP, and responds similarly to immunologic therapies.3 CIDP clinical course may be poorly responsive to conventional immunologic or chemotherapy treatment.4 Consequently, allogeneic and autologous hematopoietic stem cell transplantations (HSCTs) have been proposed in selected cases.5 To our knowledge, only a single patient with concurrent IgG lambda MGUS has been treated with autologous HSCT,6 and no case of IgG kappa MGUS is reported so far.

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