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Association of Early {beta}-Amyloid Accumulation and Neuroinflammation Measured With [11C]PBR28 in Elderly Individuals Without Dementia
Objective To examine whether early β–amyloid (Aβ) accumulation and metabolic risk factors are associated with neuroinflammation in elderly individuals without dementia. Methods We examined 54…
Role of depressive symptoms in cardiometabolic diseases and subsequent transitions to all-cause mortality: an application of multistate models in a prospective cohort study
Background and purpose The role of depression in the development and outcome of cardiometabolic diseases remains to be clarified. We aimed to examine the extent…
PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE)–a population-based prospective cohort study: rationale, design and baseline participant characteristics
Background and purpose Cardiovascular diseases and dementia are two major diseases in the elderly. Atherosclerosis is associated with future vascular events and cognitive impairment. The…
Detection of Cerebral Microbleeds With Venous Connection at 7-Tesla MRI
Objective Cerebral microbleeds (MBs) are a common finding in patients with cerebral small vessel disease (CSVD) and Alzheimer disease as well as in healthy elderly…
Complex epilepsy: its all in the history
CLINICAL CASECurrent presentation The patient is right-handed, in early 50s and carries the diagnoses of generalised tonic-clonic seizures, spastic quadriparesis and severe learning disability. Generalised…
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