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Association of Cortical Hyperexcitability and Cognitive Impairment in Patients With Amyotrophic Lateral Sclerosis
Objective To determine whether cortical hyperexcitability was more prominent in cognitively impaired patients with amyotrophic lateral sclerosis (ALS). Methods Threshold tracking transcranial magnetic stimulation (TMS)…
Teaching NeuroImages: Hutchinson Sign in Herpes Zoster Ophthalmicus
A 42-year-old immunocompetent man developed left-sided orbital and temporal stabbing pain, accompanied by ipsilateral lacrimation and conjunctival injection with periorbital edema (figure 1A). On day…
Pearls & Oy-sters: Anisocoria Greater in the Dark: It's Not Just All About Horner Pupil
An initial step in the evaluation of anisocoria is assessing the pupillary light reflex. If a pupil is not responsive to light, then the near…
Executive dysfunction and risk of suicide in older adults: a population-based prospective cohort study
Objective It is uncertain what factors increases the risk of suicide in older adults without depression, and it is unknown whether executive dysfunction (ED) is…
Do we need yet another cognitive test? Free-Cog, a novel, hybrid, cognitive screening instrument
The dementia syndrome encompasses not only cognitive but also functional impairments. This is acknowledged in canonical definitions of dementia (DSM-IV) and major neurocognitive disorder (DSM-5).1…
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