What Is the Role of Sphingosine-1-Phosphate Receptors in Pain?

There is increasing evidence that the sphingosine-1-phosphate (S1P) system is a modulator of pain pathways via several receptors (S1PRs), particularly S1PR1. Dysregulation of sphingolipid metabolism and SP1R1 signaling in the periphery and in the dorsal horn leads to development of persistent neuroinflammation and nociceptive behaviors in several chronic pain models.1,2 This evidence suggests that the S1P/S1PR1 system is a suitable target for management of inflammatory and neuropathic pain.

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