Factors predicting loss of independence and mortality in frontotemporal lobar degeneration

Frontotemporal lobar degeneration (FTLD) is a complex clinicopathological concept comprising several fatal neurodegenerative diseases. Clinically, behavioural change, language impairment, semantic memory deficits, motor neuron signs, parkinsonism and apraxia can develop in various orders.1 2 Pathologically, tau, transactive response DNA-binding protein 43 kDa and fused in sarcoma are major components of diagnostic lesions of various pathological disease entities. Such clinicopathological complexity may make predicting a longitudinal course difficult in the early stage. On the other hand, most families hope to know the details of the course of a disease and to get practical advice helpful for their life. Researchers also have had a strong interest in this issue.3 4

Murley et al5 used a transdiagnostic approach to survival in an epidemiological cohort in the UK, examining the association between clinical features, independence and survival in 365 patients with FTLD. Clinical diagnoses varied,…

Read article at journal's website

Related Articles


Your email address will not be published.