Factors predicting loss of independence and mortality in frontotemporal lobar degeneration

Frontotemporal lobar degeneration (FTLD) is a complex clinicopathological concept comprising several fatal neurodegenerative diseases. Clinically, behavioural change, language impairment, semantic memory deficits, motor neuron signs, parkinsonism and apraxia can develop in various orders.1 2 Pathologically, tau, transactive response DNA-binding protein 43 kDa and fused in sarcoma are major components of diagnostic lesions of various pathological disease entities. Such clinicopathological complexity may make predicting a longitudinal course difficult in the early stage. On the other hand, most families hope to know the details of the course of a disease and to get practical advice helpful for their life. Researchers also have had a strong interest in this issue.3 4

Murley et al5 used a transdiagnostic approach to survival in an epidemiological cohort in the UK, examining the association between clinical features, independence and survival in 365 patients with FTLD. Clinical diagnoses varied,…

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