Hypothyroidism is associated with prolonged COVID-19-induced anosmia: a case-control study

Since the onset of COVID-19 pandemic, an exponentially increasing body of data suggests that infection with SARS-CoV-2 affects multiple organs with short-term and long-term outcomes that remain still unknown.1 Viral effects on thyroid function can, inevitably, lead to multisystem involvement, as thyroid hormones affect the development and function of virtually all human cells, including neural maturation of olfactory receptor neurons.2 A recent prospective observational study by Lui et al found abnormal thyroid function tests, defined as deranged thyroid-stimulating hormone (TSH) and/or free thyroxine (fT4) and/or free triiodothyronine (fT3) in 25 patients (13.1%), suggesting that SARS-CoV-2 might directly induce viral thyroiditis.3 Moreover, low fT3 values were independently associated with an increased likelihood for clinical deterioration; the researchers concluded that ‘there may be a direct effect of SARS-CoV-2 on thyroid function, potentially leading to exacerbation of pre-existing autoimmune thyroid disease’.3 However, it was not…

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