IVIG and Small Fiber Neuropathy: The Ongoing Search for Evidence

Small fiber neuropathy is a disorder of the thinly myelinated and unmyelinated nerve fibers most commonly presenting in a length-dependent form, but non–length-dependent neuropathies are seen in a small subset of patients.1 As in many other neuropathies, many underlying diseases may cause damage to the small nerve fibers, including diabetes, sarcoid, and Sjögren syndrome. There are also rare genetic forms such as Fabry disease and transthyretin amyloidosis. Small fiber neuropathies are characterized by is disruption to pain, thermal sensitivity, and autonomic nerve fibers.1 Clinically, neuropathic pain is the most common complaint.

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