Amyotrophic Lateral Sclerosis With Positive Anti-Acetylcholine Receptor Antibodies. Case Report and Review of the Literature

myneuronews May 24, 2021

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Myasthenia gravis is a nerve–muscle junction disease, for which the most specific test is an increase in the anti-acetylcholine receptor antibodies (anti-AChR-Abs) titer. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting both upper and lower motor neurons. Positive AChR-Ab in patients with pure ALS are exceedingly rare. We report the case of a patient with confirmed ALS and very high levels of AChR-Ab and review the literature on this topic.

Antibodies to LRP4 and Agrin Are Pathogenic in Myasthenia Gravis: At the Junction Where It Happens

Autoimmune myasthenia gravis (MG) is a T-cell–dependent, B-cell/antibody–mediated disease. The clinical symptoms and signs, as well as the clinical neurophysiologic and pharmacologic dysfunction, are due…

myneuronews September 6, 2021

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Seizure-related 6 homolog like 2 autoimmunity: Neurologic syndrome and antibody effects

Objective To describe the clinical syndrome of 4 new patients with seizure-related 6 homolog like 2 antibodies (SEZ6L2-abs), study the antibody characteristics, and evaluate their…

myneuronews March 2, 2021

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Argonaute Autoantibodies as Biomarkers in Autoimmune Neurologic Diseases

Objective To identify and characterize autoantibodies (Abs) as novel biomarkers for an autoimmune context in patients with central and peripheral neurologic diseases. Methods Two distinct…

myneuronews July 29, 2021

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Heterogeneity of Acetylcholine Receptor Autoantibody-Mediated Complement Activity in Patients With Myasthenia Gravis

Background and Objectives Autoantibodies targeting the acetylcholine receptor (AChR), found in patients with myasthenia gravis (MG), mediate pathology through 3 mechanisms: complement-directed tissue damage, blocking…

myneuronews April 27, 2022

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Clinical value of cell-based assays in the characterisation of seronegative myasthenia gravis

Objective Patients with myasthenia gravis without acetylcholine receptor (AChR) or muscle-specific kinase (MuSK) antibodies detected by radioimmunoprecipitation assays (RIAs) are classified as seronegative myasthenia gravis…

myneuronews July 14, 2022

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