FGFR3 Antibodies in Neuropathy: What to Do With Them?

imageObjectives:

To describe the variability of fibroblast growth factor receptor 3 (FGFR3) antibody titers in a small series of patients.

Methods:

We performed a retrospective review of patients with neuropathy and positive FGFR3 antibodies.

Results:

We report 7 patients (3 women) with an age range 44–81 years. Symptoms were acute onset in 3 and subacute onset in 4 patients. Five had neuropathic pain. Examination revealed normal large fiber function to mild/moderate predominantly sensory neuropathy and ataxia in one patient. Electrodiagnostic studies revealed normal large fiber function (3), demyelinating neuropathy (1), and mild/moderate axonal neuropathy (3). Four patients had high and 3 patients had low FGFR3 titers. Repeat testing revealed absence of antibodies in 2 patients and a significant reduction in one patient without any intervening immunotherapy.

Conclusions:

Our case series highlights the variability and inconsistency in FGFR3 antibody titers through enzyme-linked immunosorbent assay testing. These antibody titers should always be interpreted with caution in clinical context.

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