Author Response: Phenotypic Variability in ALS-FTD and Effect on Survival

myneuronews June 8, 2021

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We thank Dr. Abe for his interest in our study¹ that investigated survival in patients with amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD). Specific comparison of motor and cognitive presentations in ALS-FTD established that patients with a motor onset of their disease had reduced survival—which was associated with increased motor cortex atrophy—suggesting that survival may be mediated by motor function and other critical physiologic aspects.

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Categories: General Neurology

Editors' Note: Phenotypic Variability in ALS-FTD and Effect on Survival

Dr. Ahmed et al. examined initial presentations and cognitive and behavioral profiles in 59 patients with amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) and 39…

myneuronews June 8, 2021

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Reader Response: Phenotypic Variability in ALS-FTD and Effect on Survival

I read the article by Ahmed et al.1 and generally agree with their comments. However, I offer some insights. First, Yuasa2 reported a case of…

myneuronews June 8, 2021

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Characterizing the Clinical Features and Atrophy Patterns of MAPT-Related Frontotemporal Dementia With Disease Progression Modeling

Background and Objective Mutations in the MAPT gene cause frontotemporal dementia (FTD). Most previous studies investigating the neuroanatomical signature of MAPT mutations have grouped all…

myneuronews August 31, 2021

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Progressive Neurochemical Abnormalities in Cognitive and Motor Subgroups of Amyotrophic Lateral Sclerosis: A Prospective Multicenter Study

Objective To evaluate progressive cerebral degeneration in amyotrophic lateral sclerosis (ALS) by assessing alterations in N-acetylaspartate (NAA) ratios in the motor and prefrontal cortex within…

myneuronews August 24, 2021

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In vivo detection of damage in multiple sclerosis cortex and cortical lesions using NODDI

Objective To characterise in vivo the microstructural abnormalities of multiple sclerosis (MS) normal-appearing (NA) cortex and cortical lesions (CLs) and their relations with clinical phenotypes…

myneuronews November 20, 2021

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