Clinical implication of stimulation-induced dyskinaesia in globus pallidus deep brain stimulation for advanced Parkinsons disease

Introduction

Deep brain stimulation (DBS) has been proven effective in improving motor symptoms and reducing levodopa-induced dyskinaesia (LID) of advanced Parkinson’s disease (PD). DBS for PD targets either the subthalamic nucleus (STN) or the globus pallidus interna (GPi). The therapeutic effects on motor symptoms are similar between STN and GPi DBS.1 However, it has been reported that GPi DBS is more effective in improving LID. Thus, GPi DBS may be preferred in patients with severe LID.1

Stimulation-induced dyskinaesia (SID) can be observed in patients who undergo DBS. SID in patients with PD who undergo STN DBS may indicate proper positioning of the lead, and is considered to be a good prognostic factor for motor outcome.2 SID may also develop in GPi DBS, and dorsal GPi or globus pallidus externa (GPe) stimulation in particular may be associated with SID.3 However, little is known about…

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