Parotid Gland Injections of Botulinum Toxin A Are Effective in Treating Sialorrhea in Amyotrophic Lateral Sclerosis


The objective of this study was to determine the safety and efficacy of botulinum toxin A in ameliorating refractory sialorrhea and improving quality of life in patients with amyotrophic lateral sclerosis.

Materials and Methods:

Six patients with bulbar ALS received bilateral parotid gland injections of botulinum toxin A.


No adverse effects occurred. Tissue use decreased in 5 of 7 patients at a dose of 10 units and in 3 of 4 patients at a dose of 20 units. Self-reported quality of life did not change in most.


Parotid gland injections of botulinum toxin appear safe and may be helpful in some patients with ALS for the treatment of sialorrhea.


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