Reader Response: Association of Age at Onset and First Symptoms With Disease Progression in Patients With Metachromatic Leukodystrophy
Kehrer et al.1 categorized different onset forms of metachromatic leukodystrophies based on first symptoms at onset and disease progression. The genotypes associated with each of these categories seem to indicate that earlier symptom onset is associated with more severe arylsulfatase A (ARSA) deficiency.
Responses