A Stroke Is a Stroke, With or Without a Visible Infarct

Stroke and dementia are common; cerebrovascular disease causes cognitive impairment; and cognitive decline is a major risk factor for stroke, particularly in older patients. Despite this, relatively little is known about associations between vascular and neurodegenerative features on neuroimaging (cortical or lacunar infarcts, white matter hyperintensities [WMH], total or regional brain atrophy) or whether these vary with stroke symptoms. Yet this is likely to inform prognosis for individuals and improve understanding of vascular causes of neurodegeneration.

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