We are grateful to Dr. Heldner for the interest in our research.1 We all agree that a RCT is needed. The ENDOLOW trial (NCT04167527), which has a sample size goal of 200, started recruitment in September 2020; the trial is slated to complete in early 2023. The French MOSTE trial (NCT03796468) will evaluate endovascular therapy (EVT) in large vessel occlusion (LVO) acute ischemic stroke with minor symptoms (NIHSS < 6) in patients last seen well within 24 hours. This trial has just started recruitment in June 2020 and is planning to enroll 824 patients. Hopefully, these studies will shed more light on the clinical benefit of EVT in low NIHSS LVO strokes.