MCI Criteria in ADNI: Meeting Biological Expectations

In his Clinical Note, “Amnestic MCI in ADNI: Maybe Not Enough Memory Impairment?” Duff1 raises important issues regarding the diagnosis of mild cognitive impairment (MCI). As he comments, MCI is often a transitional condition between the cognitive changes of aging and dementia. The criteria for MCI have been reasonably consistent and accepted, but the implementation of the criteria has posed significant issues.2,3

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