Reduced blood flow velocity in lenticulostriate arteries of patients with CADASIL assessed by PC-MRA at 7T

Introduction

Previous studies reported cerebral hypoperfusion ocurred in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).1 2 As a cerebral small vessels disease, the reduction of blood flow velocity in cerebral small arteries may precede cerebral hypoperfusion and lesions formation. Due to the limitations of spatial resolution, conventional methods failed to detect the velocity of cerebral small vessels. Ultrahigh field MRI provided us a non-invasive way to investigate the velocity in lenticulostriate arteries (LSAs) of patients with CADASIL.3–5 Assessing blood flow velocity of small arteries can monitor the progress of the disease in long-term follow-up of patients.

Materials and methods

We enrolled 32 patients with CADASIL and 34 healthy controls from September 2019 to September 2020 at Peking University First Hospital. Details of subject selection, clinical assessment, MRI acquisition and analysis were described in , , ….

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