Clinical and biological features of cerebral venous sinus thrombosis following ChAdOx1 nCov-19 vaccination

Vaccines for COVID-19 were developed with unprecedented speed and since January 2021, the AstraZeneca/Oxford University ChAdOx1 nCoV-19 vaccine has been administered to over 400 million people globally.1 In April 2021, the Medicines and Healthcare products Regulatory Agency (MHRA) and the European Medicines Agency reported a possible association between ChAdOx1 nCoV-19 and a rare syndrome of unusual site thrombosis combined with thrombocytopenia, termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Frequency of VITT varies across age groups. Overall, 411 cases of VITT have been reported to the MHRA by 21 July 2021 with fatality rate of 17.76% (73/411).2

We report our experience of four VITT cases from a single tertiary referral centre in London, UK, who suffered cerebral venous sinus thrombosis (CVST) with or without thrombosis elsewhere. Baseline clinical and laboratory features are shown in table 1. Informed written consent was obtained from all patients before publication. All…

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