Reader Response: What Is the Mechanism of Therapeutic and Adverse Effects of Gabapentinoids?

Dr. Benarroch’s article about gabapentinoids describes that the α2 subunit of voltage-gated calcium channels (VGCC) allows for neuronal calcium influx. A2 is expressed in Purkinje cells, which use gamma aminobutyric acid (GABA) as a neurotransmitter. The author states that gabapentinoids inhibit the α2 subunit and reduce neurotransmitter release, resulting in the induction of cerebellar ataxia.1,2

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