Teaching NeuroImage: Notched Delta and Angelman Syndrome

We report a 9-year-old boy with a history of Angelman syndrome (AS) with associated epilepsy, behavioral issues, intellectual disability, and sleep disturbance. Genetic testing revealed a methylation imprinting defect, thereby confirming the diagnosis of AS. His seizures were well-controlled on monotherapy with clobazam and he underwent a routine EEG (figure), which showed a notched delta pattern.

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