Reader Response: Guillain-Barre Syndrome in the Placebo and Active Arms of a COVID-19 Vaccine Clinical Trial

Caution is necessary because vaccines may not have just one effect on the risk of Guillain-Barré syndrome (GBS) but a dual effect. Vaccination reduces the risk of GBS by decreasing the risk of infection. On the other hand, vaccines also have a direct effect that increases the risk of GBS by producing antibodies that cross-react with antigens of the peripheral nerves.

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