Early Experience With Tenecteplase at a Comprehensive Stroke Center

Purpose of Review

Tenecteplase has been studied and recommended as an alternative thrombolytic agent in patients with acute stroke. A brief review of clinical trials and guidelines pertinent to our clinical decision algorithm is described. This is followed by operational steps that were made to create and implement a clinical pathway based on available evidence in which tenecteplase is used in select patients with stroke at our comprehensive stroke center.

Recent Findings

A number of patients have been treated at our center with IV tenecteplase. A case is presented to illustrate the successful implementation of this new process.


Development of our protocol is discussed in detail to enable other centers to create their own clinical pathways for thrombolytic treatment of acute ischemic stroke using tenecteplase.

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