Reader Response: Automated Quantitative Pupillometry in the Critically Ill: A Systematic Review of the Literature

We read with interest the systematic review by Opic et al.,1 which addressed the presence of potential confounders for outcome prediction in critically ill patients with automated pupillometry. Standard pupil variables such as size and constriction velocity were considered together with the Neurologic Pupil Index (NPI), which is not influenced by medications or the environment.2

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