Author Response: Mediterranean Diet, Alzheimer Disease Biomarkers, and Brain Atrophy in Old Age

We thank Dr. Brenner for the insightful comment on our article.1 We agree that in the context of a Mediterranean diet, several bioactive compounds—including spermidine—are highly interesting for preventing neurodegeneration and dementia. For example, this hypothesis could be further clarified in intervention studies with spermidine supplementation.2 Notable results have been recently provided by the LipiDiDiet clinical trial showing how an early and prolonged multinutrient intervention slowed the decline on cognitive and brain outcomes in the prodromal Alzheimer stages.3

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