Respiratory support in a population-based ALS cohort: demographic, timing and survival determinants

Introduction

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease leading to a progressive loss of motor function and cognitive impairment of the frontotemporal type (FTD). Respiratory failure is a common symptom and can be treated with non-invasive mechanical ventilation (NIMV) and/or invasive mechanical ventilation (IMV) via tracheostomy.1 Studies on NIMV report a quite wide range of survival time, due to the heterogeneity of the clinical setting and patients’ characteristics, and very few data are available about NIMV and IMV in population-based cohorts.2 3

The aim of this study was to assess the outcome and prognostic determinants of ventilatory supports in a large population-based cohort of patients with ALS.

Methods

The study population includes all patients with ALS diagnosed from 2008 to 2015 in the prospective population-based Piemonte and Valle d’Aosta Register for ALS. Demographic and clinical information, including those related to NIMV/IMV, were collected. The determinants…

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