December 9, 2023

Low limb pure sensory axonal neuropathy refers to a type of peripheral neuropathy that primarily affects the sensory nerves of the lower limbs, causing symptoms such as numbness, tingling, and pain, without significantly impacting motor function. The causes of this condition are diverse, and its management is tailored to the underlying etiology.


  1. Diabetes Mellitus: One of the most common causes of peripheral neuropathy. Typically presents as a symmetric, length-dependent sensorimotor polyneuropathy, but can also manifest as a purely sensory form.
  2. Vitamin Deficiencies: Especially deficiencies in vitamins B12, B1 (thiamine), B6 (pyridoxine), and E.
  3. Toxic Exposures: Including alcohol abuse, chemotherapy agents (like platinum compounds, taxanes), and heavy metals (lead, arsenic, mercury).
  4. Autoimmune Disorders: Such as Sjögren’s syndrome, systemic lupus erythematosus, and rheumatoid arthritis.
  5. Paraproteinemic Neuropathies: Associated with disorders like multiple myeloma or monoclonal gammopathy of undetermined significance (MGUS).
  6. Infectious Diseases: HIV, Lyme disease, and leprosy can cause peripheral neuropathy.
  7. Hereditary Neuropathies: Such as Charcot-Marie-Tooth disease, although these more commonly affect motor nerves.
  8. Idiopathic: In some cases, the cause remains unknown despite thorough investigation.


  1. Blood Tests: To look for diabetes, vitamin deficiencies, thyroid dysfunction, renal function, liver function, and inflammatory or autoimmune markers. Serum protein electrophoresis and immunofixation can identify paraproteinemias.
  2. Electromyography and Nerve Conduction Studies: To confirm the diagnosis and characterize the type of neuropathy (axonal vs. demyelinating, sensory vs. motor).
  3. Lumbar Puncture: If an inflammatory or infectious cause is suspected.
  4. Skin Biopsy: To evaluate small fiber neuropathy, which may not be detected on standard nerve conduction studies.
  5. Genetic Testing: If a hereditary neuropathy is suspected based on family history and clinical presentation.


  1. Addressing Underlying Causes: Such as optimizing glycemic control in diabetes, correcting vitamin deficiencies, or treating autoimmune or infectious diseases.
  2. Pain Management: Medications like gabapentin, pregabalin, tricyclic antidepressants (e.g., amitriptyline), and selective serotonin-norepinephrine reuptake inhibitors (e.g., duloxetine) are often used to manage neuropathic pain.
  3. Physical Therapy and Rehabilitation: To maintain mobility and prevent complications.
  4. Lifestyle Modifications: Including regular exercise, foot care (especially in diabetic patients), and avoiding toxins or medications that could worsen neuropathy.
  5. Treatment of Associated Conditions: Such as chemotherapy-induced neuropathy, where modifying the chemotherapeutic regimen may be necessary.
  6. Immunomodulatory Therapies: In cases of autoimmune-associated neuropathy, treatments such as steroids, IVIG, or plasmapheresis might be considered.

Each patient’s treatment plan should be individualized, taking into account the specific etiology of the neuropathy, symptom severity, and any comorbid conditions.

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