Alicia Gonzalez‐Martinez, Daniel Romero‐Palacián, Julio Dotor García‐Soto, Pedro Sánchez, Gemma Reig Roselló, Gustavo Zapata Wainberg

Alicia Gonzalez‐Martinez, Daniel Romero‐Palacián, Julio Dotor García‐Soto, Pedro Sánchez, Gemma Reig Roselló, Gustavo Zapata Wainberg January 18, 2019


To report a case of reversible cerebral vasoconstriction syndrome (RCVS) possibly precipitated by tocilizumab.


Immunosuppressant drugs are a rare cause of reversible cerebral vasoconstriction, a syndrome characterized by segmental vasospasm. However, although it is considered a reversible process that resolves within 3 months, the cerebral vasoconstriction over time may lead to severe complications such as strokes.… Read More...

Kai‐Uwe Kern, Myriam Schwickert‐Nieswandt, Christian Maihöfner, Charly Gaul January 18, 2019


Trigeminal neuralgia is difficult to treat and shows upregulation of sodium channels. The expectorant ambroxol acts as a strong local anesthetic, about 40 times stronger than lidocaine. It preferentially inhibits the channel subtype Nav1.8, expressed especially in nociceptive C‐fibers.… Read More...

Xin Tong, Dongmei An, Fenglai Xiao, Du Lei, Running Niu, Wei Li, Jiechuan Ren, Wenyu Liu, Yingying Tang, Le Zhang, Baiwan Zhou, Qiyong Gong, Dong Zhou January 18, 2019



To explore the real‐time effects of interictal epileptiform discharges (IEDs) on hippocampus and amygdala functional connectivity (FC) in unilateral temporal lobe epilepsy (TLE).


Patients with unilateral TLE were recruited and underwent simultaneous electroencephalography–functional magnetic resonance imaging (EEG‐fMRI) scanning.… Read More...

Mirja Steinbrenner, Alexander B. Kowski, Martin Holtkamp January 18, 2019



Despite the obvious advantages of resective surgery in patients with drug‐resistant focal epilepsy, namely high probability of seizure freedom, decreased mortality, and increased quality of life, referral rates from physicians and approval rates by patients for presurgical assessment remain constantly low.… Read More...

Jon T. Willie, James G. Malcolm, Matthew A. Stern, Lindsay O. Lowder, Stewart G. Neill, Brian T. Cabaniss, Daniel L. Drane, Robert E. Gross January 18, 2019



Magnetic resonance (MR) thermography–guided laser interstitial thermal therapy, or stereotactic laser ablation (SLA), is a minimally invasive alternative to open surgery for focal epilepsy caused by cerebral cavernous malformations (CCMs). We examined the safety and effectiveness of SLA of epileptogenic CCMs.… Read More...

Véronique Latreille, Barbara A. Dworetzky, Gaston Baslet, Milena Pavlova January 18, 2019

Poor sleep is a frequent complaint of patients with psychogenic non-epileptic seizures (PNES). Our group has recently reported that PNES subjects more frequently complained of poor sleep patterns relative to those with epilepsy [1], however the study was limited by use of a single item from the Beck Depression Inventory to assess changes in sleep patterns.… Read More...

Phuuwadith Wattanachayakul, Pongprueth Rujirachun, Patompong Ungprasert January 18, 2019

Background: Recent studies have suggested that patients with chronic rhinosinusitis (CRS) may have a higher risk of stroke although the data are still limited. The current systematic review and meta-analysis was conducted with the aims to identify all studies that investigated this relationship and summarize their results together to better characterize the risk of stroke among patients with CRS.… Read More...

Marisa Distefano, Rosalinda Calandrelli, Vincenzo Arena, Alessandro Pedicelli, Giacomo Della Marca, Fabio Pilato January 18, 2019

Background: Stroke is a common neurological complication of infective endocarditis (IE) and it is associated with increased morbidity and mortality but infective endocarditis in acute stroke setting is hard to discover. Material and methods: A 75-year-old man referred to hospital for the onset of left hemiparesis and dysarthria.… Read More...

Zhengbao Zhu, Lihua Chen, Daoxia Guo, Chongke Zhong, Aili Wang, Xiaoqing Bu, Tan Xu, Jianhui Zhang, Zhong Ju, Libing Guo, Jintao Zhang, Dong Li, Chung-Shiuan Chen, Jing Chen, Yonghong Zhang, Jiang He January 18, 2019

Background: The effect of serum rheumatoid factor (RF) on poststroke cognitive impairment remains unknown. We aimed to investigate the association of serum RF in the acute phase with cognitive impairment at 3 months after ischemic stroke onset. Methods: Our study was based on a random sample from the China Antihypertensive Trial in Acute Ischemic Stroke, a total of 582 patients from 7 of 26 participating sites of the trial with serum RF levels were included in this analysis.… Read More...

C. Warren Olanow, Margherita Torti, Karl Kieburtz, Mika Leinonen, Laura Vacca, Paola Grassini, Adam Heller, Ephraim Heller, Fabrizio Stocchi January 17, 2019



Laboratory and clinical evidence indicate that continous delivery of levodopa is associated with reduced motor complications compared to standard intermittent levodopa.


To assess the pharmacokinetics and efficacy of continuous oral delivery of l‐dopa/carbidopa in PD patients with motor fluctuations.… Read More...

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