van Eijk, R. P. A., Jones, A. R., Sproviero, W., Shatunov, A., Shaw, P. J., Leigh, P. N., Young, C. A., Shaw, C. E., Mora, G., Mandrioli, J., Borghero, G., Volanti, P., Diekstra, F. P., van Rheenen, W., Verstraete, E., Eijkemans, M. J. C., Veldink, J. H., Chio, A., Al-Chalabi, A., van den Berg, L. H., van Es, M. A., For UKMND-LiCALS and LITALS Study Group

Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials

van Eijk, R. P. A., Jones, A. R., Sproviero, W., Shatunov, A., Shaw, P. J., Leigh, P. N., Young, C. A., Shaw, C. E., Mora, G., Mandrioli, J., Borghero, G., Volanti, P., Diekstra, F. P., van Rheenen, W., Verstraete, E., Eijkemans, M. J. C., Veldink, J. H., Chio, A., Al-Chalabi, A., van den Berg, L. H., van Es, M. A., For UKMND-LiCALS and LITALS Study Group October 5, 2017

Objective:

To assess whether genetic subgroups in recent amyotrophic lateral sclerosis (ALS) trials responded to treatment with lithium carbonate, but that the treatment effect was lost in a large cohort of nonresponders.

Methods:

Individual participant data were obtained from 3 randomized trials investigating the efficacy of lithium carbonate.… Read More...

Polycystic kidney disease among 4,436 intracranial aneurysm patients from a defined population

Nurmonen, H. J., Huttunen, T., Huttunen, J., Kurki, M. I., Helin, K., Koivisto, T., von und zu Fraunberg, M., Jääskeläinen, J. E., Lindgren, A. E. October 5, 2017

Objective:

To define the association of autosomal dominant polycystic kidney disease (ADPKD) with the characteristics of aneurysmal subarachnoid hemorrhage (aSAH) and unruptured intracranial aneurysm (IA) disease.

Methods:

We fused data from the Kuopio Intracranial Aneurysm database (n = 4,436 IA patients) and Finnish nationwide registries into a population-based series of 53 IA patients with ADPKD to compare the aneurysm- and patient-specific characteristics of IA disease in ADPKD and in the general IA population, and to identify risks for de novo IA formation.… Read More...

The social and economic burden of frontotemporal degeneration

Galvin, J. E., Howard, D. H., Denny, S. S., Dickinson, S., Tatton, N. October 5, 2017

Objective:

To quantify the socioeconomic burden of frontotemporal degeneration (FTD) compared to previously published data for Alzheimer disease (AD).

Methods:

A 250-item internet survey was administered to primary caregivers of patients with behavioral-variant FTD (bvFTD), primary progressive aphasia, FTD with motor neuron disease, corticobasal syndrome, or progressive supranuclear palsy.… Read More...

Multicenter clinical assessment of improved wearable multimodal convulsive seizure detectors

Francesco Onorati, Giulia Regalia, Chiara Caborni, Matteo Migliorini, Daniel Bender, Ming-Zher Poh, Cherise Frazier, Eliana Kovitch Thropp, Elizabeth D. Mynatt, Jonathan Bidwell, Roberto Mai, W. Curt LaFrance, Andrew S. Blum, Daniel Friedman, Tobias Loddenkemper, Fatemeh Mohammadpour-Touserkani, Claus Reinsberger, Simone Tognetti, Rosalind W. Picard October 5, 2017

Summary

Objective

New devices are needed for monitoring seizures, especially those associated with sudden unexpected death in epilepsy (SUDEP). They must be unobtrusive and automated, and provide false alarm rates (FARs) bearable in everyday life. This study quantifies the performance of new multimodal wrist-worn convulsive seizure detectors.

… Read More...

Docosahexaenoic acid (DHA) is a beneficial replacement treatment for Spinocerebellar Ataxia 38 (SCA38)

M Manes, A Alberici, E Di Gregorio, L Boccone, E Premi, N Mitro, M.P. Pasolini, C Pani, B Paghera, D Perani, L Orsi, C Costanzi, M Ferrero, A Zoppo, F Tempia, D Caruso, M Grassi, A Padovani, A Brusco, B Borroni October 4, 2017

Abstract

Objective: Spinocerebellar Ataxia 38 (SCA38) is caused by mutations in the ELOVL5 gene, which encodes an elongase involved in the synthesis of polyunsatured fatty acids, including docosahexaenoic acid (DHA). As a consequence, DHA is significantly reduced in the serum of SCA38 subjects.

… Read More...

Pedestrian safety in patients with Parkinson’s disease: A case-control study

Kristin J. Ford, Allen Joop, Raima A. Memon, Kimberly H. Wood, Karlene Ball, Gary R. Cutter, David C. Schwebel, Amy W. Amara October 4, 2017

ABSTRACT

Background

Patients with Parkinson’s disease experience debilitating motor symptoms as well as nonmotor symptoms, such as cognitive dysfunction and sleep disorders. This constellation of symptoms has the potential to negatively influence pedestrian safety. The objective of this study was to investigate the association of motor symptoms, daytime sleepiness, impaired vigilance, and cognitive dysfunction with pedestrian behavior in patients with Parkinson’s disease and healthy older adults.

… Read More...

MyNeuroNews.com 2014-2018

Andoird App
Loading...