Brandy B. Ma, John Bloch, Allan Krumholz, Jennifer L. Hopp, Perry J. Foreman, Carl A. Soderstrom, Mary A. Scottino, Martha Matsumoto, Gregory L. Krauss

Brandy B. Ma, John Bloch, Allan Krumholz, Jennifer L. Hopp, Perry J. Foreman, Carl A. Soderstrom, Mary A. Scottino, Martha Matsumoto, Gregory L. Krauss September 3, 2017

Summary

Objective

Driving regulations for people with seizures vary widely throughout the United States and the world. Maryland updated their guidelines in 2003 to reflect those of a U.S. consensus guideline requiring a minimum 3-month seizure-free period as well as an individual risk assessment by a Medical Advisory Board (MAB).

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Taku Uchida, Christoph Lossin, Yukiko Ihara, Masanobu Deshimaru, Yuchio Yanagawa, Susumu Koyama, Shinichi Hirose September 3, 2017

Summary

Objective

Mutations of the KCNQ2 gene, which encodes the Kv7.2 subunit of voltage-gated M-type potassium channels, have been associated with epilepsy in the neonatal period. This developmental stage is unique in that the neurotransmitter gamma aminobutyric acid (GABA), which is inhibitory in adults, triggers excitatory action due to a reversed chloride gradient.

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Xuan Huang, Chengwen Zhou, Mengnan Tian, Jing-Qiong Kang, Wangzhen Shen, Kelienne Verdier, Aurea Pimenta, Robert L. MacDonald September 3, 2017

Summary

Objective

The mutant γ-aminobutyric acid type A (GABAA) receptor γ2(Q390X) subunit (Q351X in the mature peptide) has been associated with the epileptic encephalopathy, Dravet syndrome, and the epilepsy syndrome genetic epilepsy with febrile seizures plus (GEFS+). The mutation generates a premature stop codon that results in translation of a stable truncated and misfolded γ2 subunit that accumulates in neurons, forms intracellular aggregates, disrupts incorporation of γ2 subunits into GABAA receptors, and affects trafficking of partnering α and β subunits.

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Ben F. M. Wijnen, Loes A. M. Leenen, Reina J. A. Kinderen, Caroline M. Heugten, Marian H. J. M. Majoie, Silvia M. A. A. Evers September 3, 2017

Summary

Objective

The objective of this (trial-based) economic evaluation was, from a societal perspective, to compare the cost-effectiveness of a multicomponent self-management intervention (MCI) with care as usual (CAU) in adult patients with epilepsy over a 12-month period.

Methods

In a randomized-controlled trial, participants were randomized into intervention or CAU group.

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Tram Pham, Khara M. Sauro, Scott B. Patten, Samuel Wiebe, Kirsten M. Fiest, Andrew G. M. Bulloch, Nathalie Jetté September 3, 2017

Summary

The objectives of this study were to estimate the prevalence of, and factors associated with, anxiety in epilepsy. We conducted a cross-sectional analysis using data from the Neurological Disease and Depression Study. The prevalence of anxiety and associated factors were assessed using descriptive statistics and logistic regression.

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Tanja S. Kellermann, Martina Mueller, Emma G. Carter, Byron Brooks, Gigi Smith, Olivia J. Kopp, Janelle L. Wagner September 3, 2017

Summary

Objective

Proper assessment and early identification of depressive symptoms are essential to initiate treatment and minimize the risk for poor outcomes in youth with epilepsy (YWE). The current study examined the predictive utility of the Neurological Disorders Depression Inventory-Epilepsy for Youth (NDDI-E-Y) and the Neuro-QOL Depression Short Form (Neuro-QOL SF) in explaining variance in overall depressive symptoms and specific symptom clusters on the gold standard Children’s Depression Inventory-2 (CDI-2).

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Jesús-Servando Medel-Matus, Don Shin, Raman Sankar, Andrey Mazarati September 3, 2017

Summary

The objective was to determine whether the depression comorbid with epilepsy could be predicted based on inherent premorbid patterns of monoaminergic transmission. In male Wistar rats, despair-like and anhedonia-like behaviors were examined using forced swimming and taste preference tests, respectively.

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Zhan Lim, Kingsley Wong, Heather E. Olson, Ann M. Bergin, Jenny Downs, Helen Leonard September 3, 2017

Summary

Objective

Pathogenic variants involving the CDKL5 gene result in a severe epileptic encephalopathy, often later presenting with features similar to Rett syndrome. Cardinal features of epilepsy in the CDKL5 disorder include early onset at a median age of 6 weeks and poor response to antiepileptic drugs.

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Evan C. Rosenberg, Jay Louik, Erin Conway, Orrin Devinsky, Daniel Friedman September 3, 2017

Summary

Recent clinical trials indicate that cannabidiol (CBD) may reduce seizure frequency in pediatric patients with certain forms of treatment-resistant epilepsy. Many of these patients experience significant impairments in quality of life (QOL) in physical, mental, and social dimensions of health.

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Iván Sánchez Fernández, Marina Gaínza-Lein, Tobias Loddenkemper September 3, 2017

Summary

Objective

To quantify the cost-effectiveness of rescue medications for pediatric status epilepticus: rectal diazepam, nasal midazolam, buccal midazolam, intramuscular midazolam, and nasal lorazepam.

Methods

Decision analysis model populated with effectiveness data from the literature and cost data from publicly available market prices.

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