Edward Faught, François Laliberté, Zhixiao Wang, Victoria Barghout, Batool Haider, Dominique Lejeune, Guillaume Germain, Jiyoon Choi, Aneesha Wagh, Mei Sheng Duh

Edward Faught, François Laliberté, Zhixiao Wang, Victoria Barghout, Batool Haider, Dominique Lejeune, Guillaume Germain, Jiyoon Choi, Aneesha Wagh, Mei Sheng Duh September 3, 2017

Summary

Objective

The purpose of this study was to evaluate changes in health care resource utilization following the initiation of perampanel for the treatment of epilepsy in the United States.

Methods

Health care claims from Symphony Health’s Integrated Dataverse database between December 2012 and November 2015 were analyzed.

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Arthur Cukiert, Cristine Mella Cukiert, Jose Augusto Burattini, Pedro Paulo Mariani, Daniela Fontes Bezerra September 3, 2017

Summary

Objective

We designed a prospective, randomized, controlled, double-blind study to evaluate the efficacy of hippocampal deep brain stimulation (Hip-DBS) in patients with refractory temporary lobe epilepsy (TLE).

Methods

Sixteen adult patients with refractory TLE were studied. Patient’s workup included medical history, interictal and ictal electroencephalography (EEG), and high-resolution 1.5T magnetic resonance imaging (MRI).

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Giorgia Giussani, Elisa Bianchi, Valentina Canelli, Giuseppe Erba, Carlotta Franchi, Alessandro Nobili, Josemir W. Sander, Ettore Beghi, September 3, 2017

Summary

Objective

Rate, reasons, and predictors of antiepileptic drug (AED) discontinuation were investigated in a well-defined cohort of people with epilepsy to verify efficacy and tolerability of treatment up to 20 years from treatment initiation.

Methods

The history of AED usage in children and adults with epilepsy registered with 123 family physicians in an area of Northern Italy between 2000 and 2008 was recorded.

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Jurgen Hebbink, Hil Meijer, Geertjan Huiskamp, Stephan Gils, Frans Leijten September 3, 2017

Summary

The current opinion in epilepsy surgery is that successful surgery is about removing pathological cortex in the anatomic sense. This contrasts with recent developments in epilepsy research, where epilepsy is seen as a network disease. Computational models offer a framework to investigate the influence of networks, as well as local tissue properties, and to explore alternative resection strategies.

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Pascal Martin, Gavin P. Winston, Philippa Bartlett, Jane Tisi, John S. Duncan, Niels K. Focke September 3, 2017

Summary

Objective

Although the general utility of voxel-based processing of structural magnetic resonance imaging (MRI) data for detecting occult lesions in focal epilepsy is established, many differences exist among studies, and it is unclear which processing method is preferable. The aim of this study was to compare the ability of commonly used methods to detect epileptogenic lesions in magnetic resonance MRI-positive and MRI-negative patients, and to estimate their diagnostic yield.

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John M. Pellock, Alexis Arzimanoglou, O'Neill D'Cruz, Gregory L. Holmes, Douglas Nordli, Shlomo Shinnar, September 3, 2017

Summary

Expediting pediatric access to new antiseizure drugs is particularly compelling, because epileptic seizures are the most common serious neurological symptom in children. Analysis of antiepileptic drug (AED) efficacy outcomes of randomized controlled trials, conducted during the past 20 years in different populations and a broad range of study sites and countries, has shown considerable consistency for each drug between adult and pediatric populations.

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Carolina Ciumas, Agathe Laurent, Mani Saignavongs, Faustine Ilski, Julitta Bellescize, Eleni Panagiotakaki, Karine Ostrowsky-Coste, Alexis Arzimanoglou, Vania Herbillon, Danielle Ibarrola, Philippe Ryvlin September 3, 2017

Summary

Objective

We hypothesized that children with benign childhood epilepsy with centrotemporal spikes (BCECTS) might have altered social cognitive skills and underlying neural networks.

Methods

We studied 13 patients with BCECTS and 11 age-matched controls using event-related functional magnetic resonance imaging (fMRI) with an emotional discrimination task consisting of viewing happy, fearful, scrambled, and neutral faces.

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Mayara Vendramin Pasquetti, Letícia Meier, Samanta Loureiro, Marcelo Ganzella, Bernardo Junges, Letícia Barbieri Caus, Alexandre Umpierrez Amaral, David M. Koeller, Stephen Goodman, Michael Woontner, Diogo Onofre Gomes de Souza, Moacir Wajner, Maria Elisa Calcagnotto September 3, 2017

Summary

Objectives

Glutaric acidemia type I (GA-I) is an inherited neurometabolic disorder caused by deficiency of glutaryl-CoA dehydrogenase (GCDH) and characterized by increased levels of glutaric, 3-OH-glutaric, and glutaconic acids in the brain parenchyma. The increment of these organic acids inhibits glutamate decarboxylase (GAD) and consequently lowers the γ-aminobutyric acid (GABA) synthesis.

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Monica Puligheddu, Miriam Melis, Giuliano Pillolla, Giulia Milioli, Liborio Parrino, Giovanni Mario Terzano, Sonia Aroni, Claudia Sagheddu, Francesco Marrosu, Marco Pistis, Anna Lisa Muntoni September 3, 2017

Summary

Objective

Nocturnal frontal lobe epilepsy (NFLE) is an idiopathic partial epilepsy with a family history in about 25% of cases, with autosomal dominant inheritance (autosomal dominant NFLE [ADNFLE]). Traditional antiepileptic drugs are effective in about 55% of patients, whereas the rest remains refractory.

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Emily L. Johnson, Peter W. Kaplan September 3, 2017

Summary

Objective

Approximately 25 million individuals older than age 15 identify as transgender, representing about 0.3–0.9% of the world’s population. The aim of this paper is to identify and describe important medical and social considerations facing transgender persons with epilepsy.

Methods

We performed literature searches on the following terms: transgender AND epilepsy, transgender AND neurology, gender dysphoria AND epilepsy, gender dysphoria AND neurology.

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