Luigi Maccotta, Mayra A. Lopez, Babatunde Adeyemo, Beau M. Ances, Brian K. Day, Lawrence N. Eisenman, Joshua L. Dowling, Eric C. Leuthardt, Bradley L. Schlaggar, Robert Edward Hogan

Luigi Maccotta, Mayra A. Lopez, Babatunde Adeyemo, Beau M. Ances, Brian K. Day, Lawrence N. Eisenman, Joshua L. Dowling, Eric C. Leuthardt, Bradley L. Schlaggar, Robert Edward Hogan September 3, 2017

Summary

Objectives

Specific changes in the functional connectivity of brain networks occur in patients with epilepsy. Yet whether such changes reflect a stable disease effect or one that is a function of active seizure burden remains unclear. Here, we longitudinally assessed the connectivity of canonical cognitive functional networks in patients with intractable temporal lobe epilepsy (TLE), both before and after patients underwent epilepsy surgery and achieved seizure freedom.

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Tyler E. Gaston, E. Martina Bebin, Gary R. Cutter, Yuliang Liu, Jerzy P. Szaflarski, September 3, 2017

Summary

Objective

To identify potential pharmacokinetic interactions between the pharmaceutical formulation of cannabidiol (CBD; Epidiolex) and the commonly used antiepileptic drugs (AEDs) through an open-label safety study. Serum levels were monitored to identify interactions between CBD and AEDs.

Methods

In 39 adults and 42 children, CBD dose was started at 5 mg/kg/day and increased every 2 weeks by 5 mg/kg/day up to a maximum of 50 mg/kg/day.

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Simone Beretta, Davide Carone, Clara Zanchi, Elisa Bianchi, Marta Pirovano, Claudia Trentini, Giada Padovano, Matteo Colombo, Diletta Cereda, Sofia Scanziani, Giorgia Giussani, Sara Gasparini, Graziella Bogliun, Carlo Ferrarese, Ettore Beghi, September 3, 2017

Summary

Objective

The new epilepsy definition adopted by the International League Against Epilepsy (ILAE) includes patients with one unprovoked seizure with a probability of further seizures, similar to the general recurrence risk after two unprovoked seizures, occurring in a 10-year period.

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Steven Wickens, Stephen C. Bowden, Wendyl D'Souza September 3, 2017

Summary

Objective

It is now well appreciated that benign epilepsy with centrotemporal spikes (BECTS, or more recently, ECTS) is associated with a range of cognitive and behavioral disturbances. Despite our improved understanding of cognitive functioning in ECTS, there have been to date no efforts to quantitatively synthesize the available literature within a comprehensive cognitive framework.

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