Tram Pham, Khara M. Sauro, Scott B. Patten, Samuel Wiebe, Kirsten M. Fiest, Andrew G. M. Bulloch, Nathalie Jetté

Tram Pham, Khara M. Sauro, Scott B. Patten, Samuel Wiebe, Kirsten M. Fiest, Andrew G. M. Bulloch, Nathalie Jetté September 3, 2017

Summary

The objectives of this study were to estimate the prevalence of, and factors associated with, anxiety in epilepsy. We conducted a cross-sectional analysis using data from the Neurological Disease and Depression Study. The prevalence of anxiety and associated factors were assessed using descriptive statistics and logistic regression.

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Tanja S. Kellermann, Martina Mueller, Emma G. Carter, Byron Brooks, Gigi Smith, Olivia J. Kopp, Janelle L. Wagner September 3, 2017

Summary

Objective

Proper assessment and early identification of depressive symptoms are essential to initiate treatment and minimize the risk for poor outcomes in youth with epilepsy (YWE). The current study examined the predictive utility of the Neurological Disorders Depression Inventory-Epilepsy for Youth (NDDI-E-Y) and the Neuro-QOL Depression Short Form (Neuro-QOL SF) in explaining variance in overall depressive symptoms and specific symptom clusters on the gold standard Children’s Depression Inventory-2 (CDI-2).

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Jesús-Servando Medel-Matus, Don Shin, Raman Sankar, Andrey Mazarati September 3, 2017

Summary

The objective was to determine whether the depression comorbid with epilepsy could be predicted based on inherent premorbid patterns of monoaminergic transmission. In male Wistar rats, despair-like and anhedonia-like behaviors were examined using forced swimming and taste preference tests, respectively.

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Zhan Lim, Kingsley Wong, Heather E. Olson, Ann M. Bergin, Jenny Downs, Helen Leonard September 3, 2017

Summary

Objective

Pathogenic variants involving the CDKL5 gene result in a severe epileptic encephalopathy, often later presenting with features similar to Rett syndrome. Cardinal features of epilepsy in the CDKL5 disorder include early onset at a median age of 6 weeks and poor response to antiepileptic drugs.

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Evan C. Rosenberg, Jay Louik, Erin Conway, Orrin Devinsky, Daniel Friedman September 3, 2017

Summary

Recent clinical trials indicate that cannabidiol (CBD) may reduce seizure frequency in pediatric patients with certain forms of treatment-resistant epilepsy. Many of these patients experience significant impairments in quality of life (QOL) in physical, mental, and social dimensions of health.

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Iván Sánchez Fernández, Marina Gaínza-Lein, Tobias Loddenkemper September 3, 2017

Summary

Objective

To quantify the cost-effectiveness of rescue medications for pediatric status epilepticus: rectal diazepam, nasal midazolam, buccal midazolam, intramuscular midazolam, and nasal lorazepam.

Methods

Decision analysis model populated with effectiveness data from the literature and cost data from publicly available market prices.

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Maeike Zijlmans, Gregory A. Worrell, Matthias Dümpelmann, Thomas Stieglitz, Andrei Barborica, Marcel Heers, Akio Ikeda, Naotaka Usui, Michel Le Van Quyen September 3, 2017

Summary

Objective

Technology for localizing epileptogenic brain regions plays a central role in surgical planning. Recent improvements in acquisition and electrode technology have revealed that high-frequency oscillations (HFOs) within the 80–500 Hz frequency range provide the neurophysiologist with new information about the extent of the epileptogenic tissue in addition to ictal and interictal lower frequency events.

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Jordan S. Farrell, Roberto Colangeli, Marshal D. Wolff, Alexandra K. Wall, Thomas J. Phillips, Antis George, Paolo Federico, G. Campbell Teskey September 3, 2017

Summary

A recent article by Farrell et al. characterizes the phenomenon, mechanisms, and treatment of a local and severe hypoperfusion/hypoxia event that occurs in brain regions following a focal seizure. Given the well-established role of cerebral ischemia/hypoxia in brain damage and behavioral dysfunction in other clinical settings (e.g., stroke, cerebral vasospasm), we put forward a new theory: postictal hypoperfusion/hypoxia is responsible for the negative consequences associated with seizures.

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Nicola Specchio, Marcello Bellusci, Nicola Pietrafusa, Marina Trivisano, Luca Palma, Federico Vigevano September 3, 2017

Summary

Objective

This study aimed to identify early clinical, magnetic resonance imaging (MRI), and electroencephalographic (EEG) characteristics of neuronal ceroid lipofuscinosis type 2 (CLN2) disease to enable early diagnosis, thus providing the key to early treatment, and optimized care and outcomes.

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Jesús-Servando Medel-Matus, Ashley Reynolds, Don Shin, Raman Sankar, Andrey Mazarati September 3, 2017

Summary

This study examined whether Toll-like receptors 2 (TLR2) contribute to rapid kindling epileptogenesis. A TLR2 agonist, lipoteichoic acid (LTA), LTA antibody (LTA-A), or normal saline (control) was administered daily over 3 consecutive days, unilaterally into ventral hippocampus of adult male Wistar rats.

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