De Meo, E., Moiola, L., Ghezzi, A., Veggiotti, P., Capra, R., Amato, M. P., Pagani, E., Fiorino, A., Pippolo, L., Pera, M. C., Comi, G., Falini, A., Filippi, M., Rocca, M. A.

De Meo, E., Moiola, L., Ghezzi, A., Veggiotti, P., Capra, R., Amato, M. P., Pagani, E., Fiorino, A., Pippolo, L., Pera, M. C., Comi, G., Falini, A., Filippi, M., Rocca, M. A. September 3, 2017

Objective:

To explore the structural and functional integrity of the sustained attention system in patients with pediatric multiple sclerosis (MS) and its effect on cognitive impairment.

Methods:

We enrolled 57 patients with pediatric MS and 14 age- and sex-matched healthy controls (HCs).… Read More...

Suzuki, S., Ishikawa, N., Konoeda, F., Seki, N., Fukushima, S., Takahashi, K., Uhara, H., Hasegawa, Y., Inomata, S., Otani, Y., Yokota, K., Hirose, T., Tanaka, R., Suzuki, N., Matsui, M. September 3, 2017

Objective:

To report the clinical features of myasthenia gravis (MG) induced by treatment with immune checkpoint inhibitors using 2-year safety databases based on postmarketing surveys in Japan.

Methods:

We studied 10,277 patients with cancer who had received monotherapy with either nivolumab or ipilimumab between September 2014 and August 2016.… Read More...

Li, G., Mayer, C. L., Morelli, D., Millard, S. P., Raskind, W. H., Petrie, E. C., Cherrier, M., Fagan, A. M., Raskind, M. A., Peskind, E. R. September 3, 2017

Objective:

To examine potential disease-modifying effects of statin drugs, we conducted a 12-month randomized, placebo-controlled clinical trial of simvastatin in cognitively normal adults using change in CSF Alzheimer disease biomarkers as primary outcome measure.

Methods:

Participants were 45–64 years old and statin-naive with normal cognition and normal or mildly elevated cholesterol.… Read More...

Kim, H. J., Evoli, A. September 3, 2017

Cancer and autoimmunity can be viewed as differing consequences of deranged immune responses. The overexpression of certain molecules could result in development of cancer (failure of the immune system to control tumor cell growth), whereas oversuppression of the same molecules could lead to autoimmunity (failure of the immune system to regulate autoreactive responses).… Read More...

Fullard, M. E., Thibault, D. P., Hill, A., Fox, J., Bhatti, D. E., Burack, M. A., Dahodwala, N., Haberfeld, E., Kern, D. S., Klepitskava, O. S., Urrea-Mendoza, E., Myers, P., Nutt, J., Rafferty, M. R., Schwalb, J. M., Shulman, L. M., Willis, A. W., On behalf of the Parkinson Study Group Healthcare Outcomes and Disparities Working Group September 3, 2017

Objective:

To examine rehabilitation therapy utilization for Parkinson disease (PD).

Methods:

We identified 174,643 Medicare beneficiaries with a diagnosis of PD in 2007 and followed them through 2009. The main outcome measures were annual receipt of physical therapy (PT), occupational therapy (OT), or speech therapy (ST).… Read More...

Markus, H. S., Larsson, S. C., Kuker, W., Schulz, U. G., Ford, I., Rothwell, P. M., Clifton, A., For the VIST Investigators September 3, 2017

Objective:

To compare in the Vertebral Artery Ischaemia Stenting Trial (VIST) the risks and benefits of vertebral angioplasty and stenting with best medical treatment (BMT) alone for symptomatic vertebral artery stenosis.

Methods:

VIST was a prospective, randomized, open-blinded endpoint clinical trial performed in 14 hospitals in the United Kingdom.… Read More...

Rooney, J. P. K., Visser, A. E., D'Ovidio, F., Vermeulen, R., Beghi, E., Chio, A., Veldink, J. H., Logroscino, G., van den Berg, L. H., Hardiman, O., For the Euro-MOTOR Consortium September 3, 2017

Objective:

To investigate the role of hormonal risk factors for amyotrophic lateral sclerosis (ALS) among women from 3 European countries.

Methods:

ALS cases and matched controls were recruited over 4 years in Ireland, Italy, and the Netherlands. Hormonal exposures, including reproductive history, breastfeeding, contraceptive use, hormonal replacement therapy, and gynecologic surgical history, were recorded with a validated questionnaire.… Read More...

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