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admin July 19, 2019

Isolated mitochondrial myopathy refers to the condition that mitochondrial disorders primarily affect skeletal muscle system. Here we reported a case who presented with acute respiratory failure as the initial and predominant clinical manifestation after using anesthetic drugs. The diagnosis of mitochondrial myopathy was made by histochemical findings of ragged red fibers with modified Gomori trichrome Stain in skeletal muscle biopsy and genetic detection of an A3243G point mutation in the tRNALeu (UUR) gene of mitochondrial DNA (mtDNA) in peripheral blood specimen.… Read More...

Jens Witsch, Lindsey Kuohn, Ryan Hebert, Branden Cord, Lauren Sansing, Emily J. Gilmore, David Y. Hwang, Nils Petersen, Guido J. Falcone, Charles Matouk, Kevin N. Sheth July 19, 2019

Background and Aim: The FRESH score is a tool to prognosticate long-term outcomes after spontaneous subarachnoid hemorrhage (SAH). Here, for the first time, we aimed to externally validate the disability part of FRESH using its original four score variables. Methods: A total of 107 patients with SAH were prospectively enrolled in the Yale Acute Brain Injury Biorepository between September 2014 and January 2018.… Read More...

Stephen Aradi, Eric Kaiser, Brett Cucchiara July 19, 2019

Calcitonin gene-related peptide (CGRP) is involved in nociception and neurogenic inflammation in migraine, but also serves as a potent vasodilator acting on intracranial arteries. This latter effect raises concern about the possibility of drugs inhibiting CGRP precipitating cerebral ischemia. We describe a 41-year-old woman with migraine without aura who developed a right thalamic infarction following a first dose of erenumab, a CGRP-receptor blocker.… Read More...

Lucio D'Anna, Ozan Demir, Soma Banerjee, Iqbal Malik July 19, 2019

Transcatheter Aortic Valve Implantation (TAVI) is an increasingly treatment modality for severe aortic stenosis, which is associated with a considerable peri-procedural risk of stroke. To date, the clinical safety and efficacy of Tissue plasminogen activator (tPA) and mechanical thrombectomy in stroke post-TAVI is not established.… Read More...

Hyeyoung Shin, Christopher I. Moore July 18, 2019

Gamma oscillations are hypothesized to temporally coordinate sensory encoding. Shin and Moore found a distinct subtype of fast spiking interneurons (FS) in SI that are nonsensory responsive and spike regularly at gamma intervals. These “gamma regular nonsensory FS” could potentially mediate perceptually relevant oscillations, independent of the LFP and sensory drive.… Read More...

Maria I. Maraki, Leonidas Stefanis, Mary Yannakoulia, Mary H. Kosmidis, Georgia Xiromerisiou, Efthimios Dardiotis, Georgios M. Hadjigeorgiou, Paraskevi Sakka, Nikolaos Scarmeas, Maria Stamelou July 18, 2019

Abstract

Background

Identification and characterization of Parkinson’s disease (PD) in its prodromal stage is crucial.

Objective

The objective of this study was to investigate the association between motor function and the probability of prodromal PD in a community‐dwelling older population.

Methods

We used data from a population‐based cohort of older adults (HELIAD study).… Read More...

Maria I. Maraki, Leonidas Stefanis, Mary Yannakoulia, Mary H. Kosmidis, Georgia Xiromerisiou, Efthimios Dardiotis, Georgios M. Hadjigeorgiou, Paraskevi Sakka, Nikolaos Scarmeas, Maria Stamelou July 18, 2019

Abstract

Background

Identification and characterization of Parkinson’s disease (PD) in its prodromal stage is crucial.

Objective

The objective of this study was to investigate the association between motor function and the probability of prodromal PD in a community‐dwelling older population.

Methods

We used data from a population‐based cohort of older adults (HELIAD study).… Read More...

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