Yoshitaka Yamaguchi, Mikito Hayakawa, Naoto Kinoshita, Chiaki Yokota, Toshiya Ishihara, Kazunori Toyoda

Yoshitaka Yamaguchi, Mikito Hayakawa, Naoto Kinoshita, Chiaki Yokota, Toshiya Ishihara, Kazunori Toyoda November 16, 2017

A 63-year-old woman with end-stage renal disease on maintenance hemodialysis discontinued her medication for rheumatoid arthritis with prednisolone and azathioprine. One month later, she was admitted because of consciousness disturbance and right hemiparesis. Diffusion-weighted brain magnetic resonance imaging (MRI) revealed multiple hyperintensities in her left frontal and parietal lobes.… Read More...

Yanling Liang, Jia Chen, Xuan Zheng, Zhiyi Chen, Yuming Liu, Siying Li, Xiaobo Fang November 16, 2017

The neuroprotective effects of kallidinogenase against acute cerebral infarction have been demonstrated, and the use of microbubbles has been suggested as a therapeutic mechanism for drug delivery. This study was designed to investigate the optimal parameters for preparing kallidinogenase-loaded microbubbles (KLMs) and to evaluate the effects of KLM-targeted therapy on neurogenesis and angiogenesis following experimental acute cerebral infarction in rats.… Read More...

Raffaella Willmann, Filippo Buccella, Annamaria De Luca, Miranda D. Grounds, on behalf of the 227th ENMC workshop study group November 16, 2017

• For the first time, the issue of improving translatability of preclinical results was discussed with a wide range of stakeholders representing the researchers‘ and the clinicians‘ communities, the journal editors, the funding bodies, the regulatory agencies, industry and patient representatives.• Challenges and pitfalls regarding the planning, funding, reporting and publishing of efficacy studies and confirmatory studies in animal models, the publishing of negative results and the sharing of data, were thoroughly discussed.… Read More...

Torsten Kraya, Marcus Deschauer, Pushpa Raj Joshi, Stephan Zierz, Charly Gaul November 15, 2017

Background

Mitochondrial diseases are a heterogeneous group of diseases with different phenotypes and genotypes. Headache and, particularly migraine, seems to occur often in patients with MELAS and in patients with CPEO phenotypes. The International Classification of Headache Disorders (ICHD-3 beta) has classified headache as a secondary entity only in MELAS patients.

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Catherine D. Chong, Visar Berisha, Chia-Chun Chiang, Katherine Ross, Todd J. Schwedt November 15, 2017

Objective

To investigate differences in cortical thickness in patients with persistent post-traumatic headache (PPTH) relative to healthy controls and to interrogate whether cortical morphology relates to headache burden (headache frequency, years with post-traumatic headache, PTH) in patients with PPTH.

Background

PTHs are one of the most common symptoms following concussion.

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Huma U. Sheikh, Jelena Pavlovic, Elizabeth Loder, Rebecca Burch November 15, 2017

Objective

Migraine with aura has been associated with increased risk of ischemic and hemorrhagic stroke. Prior studies have shown a further increase in risk in women using combined hormonal contraceptives (CHCs). This has led to guidelines recommending against use of CHCs in this population.

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