Gabriela F Carvalho

Soo Hyun Nam, Kanwal, Da Eun Nam, Min Hee Lee, Tae Hoon Kang, Sung-Chul Jung, Byung-Ok Choi, Ki Wha Chung April 12, 2018

• An association study was conducted between miR-149 SNP and severity of CMT1A.• The rs2292832 SNP was closely associated to the onset age and severity of CMT1A.• The TC and CC genotypes were associated with late onset and mild symptom.• The rs2292832 in miR-149 was suggested as a potential genetic modifier of CMT1A.… Read More...

admin April 11, 2018

Abstract

Despite great advances in understanding of molecular pathogenesis and achievement of a high cure rate in medulloblastoma, recurrent medulloblastomas are still dismal. Additionally, misidentification of secondary malignancies due to histological ambiguity leads to misdiagnosis and eventually to inappropriate treatment. Nevertheless, the genomic characteristics of recurrent medulloblastomas are poorly understood, largely due to a lack of matched primary and recurrent tumor tissues.… Read More...

Paul M. Brennan April 11, 2018

Journal of Neurosurgery, Ahead of Print.
OBJECTIVEGlasgow Coma Scale (GCS) scores and pupil responses are key indicators of the severity of traumatic brain damage. The aim of this study was to determine what information would be gained by combining these indicators into a single index and to explore the merits of different ways of achieving this.METHODSInformation about early GCS scores, pupil responses, late outcomes on the Glasgow Outcome Scale, and mortality were obtained at the individual patient level by reviewing data from the CRASH (Corticosteroid Randomisation After Significant Head Injury; n = 9,045) study and the IMPACT (International Mission for Prognosis and Clinical Trials in TBI; n = 6855) database.… Read More...

Gordon D. Murray April 11, 2018

Journal of Neurosurgery, Ahead of Print.
OBJECTIVEClinical features such as those included in the Glasgow Coma Scale (GCS) score, pupil reactivity, and patient age, as well as CT findings, have clear established relationships with patient outcomes due to neurotrauma. Nevertheless, predictions made from combining these features in probabilistic models have not found a role in clinical practice.… Read More...

Óscar Romero-Osorio, Sebastián Gil-Tamayo, Daniel Nariño, Diego Rosselli April 11, 2018

In patients with epilepsy, multiple factors such as ictal frequency, interictal activity and anticonvulsant therapy affect sleep architecture and quality [1]. Daytime somnolenceis the most common complaint of patients with epilepsy is [1,2]. An increase in obstructive sleep apnoea/hypopnea syndrome (OSAHS) has been documented in patients with refractory epilepsy, in whom, with an incidence as high as 33% [3], associated with a decline in the quality of life [4].… Read More...

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