Pauline Prin, Yorick Rodriguez, Jean-Marc Le Goff, Chérif Héroum, Christelle Molinero, Eric Thouvenot

Kunio Nakamura, Jacqueline T. Chen, Daniel Ontaneda, Robert J. Fox, Bruce D. Trapp September 3, 2017

Abstract

Detecting cortical demyelination in patients with multiple sclerosis (MS) is difficult. Using magnetic resonance imaging (MRI), ratio maps of T1-weighted and T2-weighted images (T1w/T2w) may be sensitive to cortical myelin levels. In this MRI-histological study, postmortem in situ scans were acquired from six cadavers with MS on a 3 Tesla MRI.

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Richard L. Yates, Margaret M. Esiri, Jacqueline Palace, Benjamin Jacobs, Rafael Perera, Gabriele C. DeLuca September 3, 2017

Objective

Neuronal loss, a key substrate of irreversible disability in multiple sclerosis (MS), is a recognized feature of MS cortical pathology of which the cause remains unknown. Fibrin(ogen) deposition is neurotoxic in animal models of MS, but has not been evaluated in human progressive MS cortex.

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Gareth Ball, Paul Aljabar, Phumza Nongena, Nigel Kennea, Nuria Gonzalez-Cinca, Shona Falconer, Andrew T.M. Chew, Nicholas Harper, Julia Wurie, Mary A. Rutherford, Serena J. Counsell, A. David Edwards September 3, 2017

Objective

Premature birth is associated with numerous complex abnormalities of white and gray matter and a high incidence of long-term neurocognitive impairment. An integrated understanding of these abnormalities and their association with clinical events is lacking. The aim of this study was to identify specific patterns of abnormal cerebral development and their antenatal and postnatal antecedents.

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David J. Irwin, Alberto Lleó, Sharon X. Xie, Corey T. McMillan, David A. Wolk, Edward B. Lee, Viviana M. Van Deerlin, Leslie M. Shaw, John Q. Trojanowski, Murray Grossman September 3, 2017

Objective

To test the hypotheses that (1) antemortem cerebrospinal fluid (CSF) tau levels correlate with postmortem tau pathology in frontotemporal lobar degeneration (FTLD) and (2) tauopathy patients have higher phosphorylated-tau levels compared to transactivation response element DNA-binding protein 43 (TDP-43) proteinopathy patients while accounting for Alzheimer’s disease (AD) copathology.

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Angelina Maric, Eszter Montvai, Esther Werth, Matthias Storz, Janina Leemann, Sebastian Weissengruber, Christian C. Ruff, Reto Huber, Rositsa Poryazova, Christian R. Baumann September 3, 2017

Abstract

Objectives: Chronic sleep restriction is highly prevalent in modern society and is in its clinical form, insufficient sleep syndrome, one of the most prevalent diagnoses in clinical sleep laboratories, with substantial negative impact on health and community burden. It reflects every-day sleep loss better than acute sleep deprivation, but its effects and particularly the underlying mechanisms remain largely unknown for a variety of critical cognitive domains, as for example risky decision-making.

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Jorien M. M. van der Burg, Sarah L. Gardiner, Albert C. Ludolph, G. Bernhard Landwehrmeyer, Raymund A. C. Roos, N. Ahmad Aziz September 3, 2017

Unintended weight loss is a hallmark of Huntington disease (HD), but it is unknown to what extent weight loss impacts the rate of disease progression. Therefore, using longitudinal data from the Enroll-HD study, we assessed the association between baseline body mass index (BMI) and the rate of clinical progression in 5,821 HD mutation carriers.

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Milan Brázdil, Martin Pail, Josef Halámek, Filip Plešinger, Jan Cimbálník, Robert Roman, Petr Klimeš, Pavel Daniel, Jan Chrastina, Eva Brichtová, Ivan Rektor, Gregory A. Worrell, Pavel Jurák September 3, 2017

Objective

In the present study, we aimed to investigate depth electroencephalographic (EEG) recordings in a large cohort of patients with drug-resistant epilepsy and to focus on interictal very high-frequency oscillations (VHFOs) between 500Hz and 2kHz. We hypothesized that interictal VHFOs are more specific biomarkers for epileptogenic zone compared to traditional HFOs.

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