Jun Nishiyama, Takayasu Mikuni, Ryohei Yasuda

Ji Liu, Kristie Conde, Peng Zhang, Varoth Lilascharoen, Zihui Xu, Byung Kook Lim, Randy J. Seeley, J. Julius Zhu, Michael M. Scott, Zhiping P. Pang October 19, 2017

Liu et al. show that GLP-1 signaling in PVN suppresses food intake and may prevent obesity. The molecular mechanism underlying the GLP-1 function in the PVN is via AMPA receptor subunit-GluA1 phosphorylation and subsequent membrane trafficking in a PKA-dependent pathway.

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Nadine Schmidt, Astrid Kollewe, Cristina E. Constantin, Sebastian Henrich, Andreas Ritzau-Jost, Wolfgang Bildl, Anja Saalbach, Stefan Hallermann, Akos Kulik, Bernd Fakler, Uwe Schulte October 19, 2017

PMCAs are fundamental for termination of Ca2+ signaling processes in many types of cells. Schmidt et al. identify Neuroplastin and Basigin as novel subunits of native PMCAs and illustrate the significance of both proteins for processing and function of PMCA complexes.… Read More...

Friedman, B. W., Irizarry, E., Solorzano, C., Latev, A., Rosa, K., Zias, E., Vinson, D. R., Bijur, P. E., Gallagher, E. J. October 19, 2017

Objective:

To determine outcomes among patients with migraine in the emergency department (ED) who receive IV hydromorphone vs IV prochlorperazine + diphenhydramine.

Methods:

This study was conducted in 2 EDs in New York City. Patients who met international criteria for migraine were eligible for participation if they had not used an opioid within the previous month.… Read More...

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