Dynamic assessment of muscle perfusion, deoxymyoglobin and phosphorylated metabolites concentrations through fast interleaved NMR acquisitions with a clinical 3T scanner

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NMR allows to quantify in vivo multiple aspects of physiological parameters such as regional perfusion, blood and tissue oxygenation, intracellular pH or high-energy phosphate metabolism. Classical NMR acquisition schemes rarely explore more than a few biological parameters during a dynamic paradigm, such as exercise or leg ischemia, and thus multiple separate experimental sessions are required at the expense of adding experimental variability on biological processes which are already multifactorial, increased length of scan time and patient discomfort.

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