Unraveling upper extremity performance in DMD: a biophysical model


Upper extremity (UE) activity scales are currently used as the golden standard for defining UE function in non-ambulant Duchenne muscular dystrophy (DMD) patients. These scales, however, are not able to explain the biophysical working mechanism behind changes in UE function. Therefore, we aimed to identify critical physiological outcome variables underlying reduced UE task performance in DMD. These critical variables were used to construct an explanatory biophysical model of the UE working mechanism in DMD.


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