Anti-HMGCR antibody positive myopathy shows bcl-2-positive lymphocyte follicles


Idiopathic inflammatory myopathies (IIM) are classified in five categories including polymyositis (PM), dermatomyositis (DM), immune-mediated necrotizing myopathy (IMNM), inclusion body myositis (IBM), and non-specific myositis. Muscle pathologies are required elements for the classification of IIM. In addition to the pathological patterns, more than 15 autoantibodies specific for myositis are already recognized. Recently, Anti-HMG-CoA reductase (HMGCR) antibody is reported to be one of the myositis-specific autoantibodies.


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