Associations between grip strength, myotonia and CTG expansion in myotonic dystrophy type 1


Myotonia and muscle weakness are two primary impairments in patients suffering from myotonic dystrophy type 1 (DM1). Both myotonia and muscle weakness are generally evidenced during maximal grip contractions and have been used as key biological markers of disease severity. Despite large inter-individual variations, the length of CTG repeat is thought to be a rough determinant of disease severity. Leukocyte DNA CTG repeat length has been found to be correlated with myotonia and with muscle strength, while other studies did not report such correlations.


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