Associations between grip strength, myotonia and CTG expansion in myotonic dystrophy type 1

0

Myotonia and muscle weakness are two primary impairments in patients suffering from myotonic dystrophy type 1 (DM1). Both myotonia and muscle weakness are generally evidenced during maximal grip contractions and have been used as key biological markers of disease severity. Despite large inter-individual variations, the length of CTG repeat is thought to be a rough determinant of disease severity. Leukocyte DNA CTG repeat length has been found to be correlated with myotonia and with muscle strength, while other studies did not report such correlations.

Read More...

Leave A Reply