Clinical epidemiology and multidimensional analysis of idiopathic inflammatory myopathies: to a classification based on myositis specific autoantibodies


The idiopathic inflammatory myopathies (or myositis) are a group of autoimmune diseases and heterogeneous in their pathophysiology and prognosis. The emergence of new biomarkers, such as myositis specific autoantibodies (MSA) seems to define more homogeneous subgroups of patients. The main objective was to propose a new unsupervised classification of IIM based on phenotypical, biological and immunological. 47 variables we were chosen to characterize 260 patients. We used multiple correspondence analysis (MCA) and hierarchical cluster analysis (HCA) to aggregate these patients in homogenous subgroups then classification and regression tree (CART) to predict the membership subgroup for a new individual.


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