Cyclophosphamide, thalidomide, and dexamethasone as alternative treatment regimen for sporadic late onset nemaline myopathy associated with monoclonal gammopathy of undetermined significance

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Sporadic late onset nemaline myopathy (SLONM) is a rare subacute progressive myopathy which muscle pathology play the crucial role in diagnosis. Without appropriate treatment, the prognosis of SLONM associated with monoclonal gammopathy of undetermined significance (MGUS) is unfavorable. Effective treatment regimens reported in the literature include high-dose intravenous mephalan with autologous stem cell transplantation and immunotherapy. We report a case of 33-year-old man with a 5-month history of proximal muscle weakness who later develop neck weakness and require tracheostomy.

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