CYLD is a possible therapeutic target for sporadic inclusion body myositis


Sporadic inclusion body myositis (sIBM) is an intractable inflammatory myopathy especially occurred in elderly people Muscle histology is characterized by a combination of inflammation including mononuclear cellular infiltrates into endomysium and non-necrotic myofibers and degeneration including sarcoplasmic aggregation of TAR DNA-binding protein of 43 kDa (TDP-43). Cylindromatosis (CYLD), which is originally identified as a tumor suppressor, is a deubiquitinase that negatively regulates activation of NF-κB pathway known for inflammation and innate immunity.


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