Muscle fiber dysfunction contributes to clinical muscle weakness in inclusion body myositis


Inclusion body myositis (IBM) is the most common acquired muscle disorder in adults over 50 years old. It is characterized by progressive muscle weakness and marked muscle atrophy, most prominent in the finger flexors and quadriceps muscle. In addition to atrophy, fatty replacement of muscle tissue contributes to clinical muscle weakness and functional decline. This study aims to investigate the contractile performance of residual muscle tissue. We included 8 participants with IBM and 12 healthy controls.


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