Potential role of exosomes in skeletal muscle fibrosis


Muscle fibrosis, the end point of most severe muscle diseases, is characterized by excessive connective tissue proliferation that progressively replaces muscle fibres. We have previously shown that cellular and circulating microRNAs (miRNAs) are involved in the process and, in particular, that the expression of the pro-fibrotic miR-21 is increased in Duchenne muscle dystrophy (DMD) fibroblasts and the anti-fibrotic miR-29 is significantly reduced in DMD myoblasts. Exosomes, small vesicles secreted by several cell types, in addition to proteins, contain mRNAs and miRNAs, and are actively involved in cell-cell communication.


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